Cancers, including breast cancer and prostate cancer, which are controlled by reproductive hormones, are targeted, and apoptosis is induced by extrinsic hormone receptor-mediated death pathways with the administration of exogenous hormones, such as estrogen, progestin, and luteinizing hormone-releasing hormone (LH-RH) [203,204]. The gene discussed is NR4A1; the disease is Familial prostate cancer.