Cancers, including breast cancer and prostate cancer, which are controlled by reproductive hormones, are targeted, and apoptosis is induced by extrinsic hormone receptor-mediated death pathways with the administration of exogenous hormones, such as estrogen, progestin, and luteinizing hormone-releasing hormone (LH-RH) [203,204]. Here, GNRH1 is linked to Familial prostate cancer.