Thermal targeting by the addition of KLAKLAKKLAKLAK (KLAK) peptide to the C-terminus of the heat-responsive biopolymer elastin-like polypeptide (ELP) and increasing the penetration ability into cells by the addition of cell-penetrating peptide sequence (SynB1) to the amino terminus of ELP, KLAKLAKKLAKLAK (KLAK) peptide showed improvement in targeting cancer cells with the application of mild hyperthermia [202]. The gene discussed is NR5A1; the disease is cancer.