They prevent the infection, cleanse the wound of debris, and release soluble mediators such as proinflammatory cytokines (interleukins: IL-1, IL-6, IL-8, and tumor necrosis factor alpha: TNF-α) and growth factors (such as PDGF, TGF-β, TGF-α, IGF-1, and FGF) that are involved in the recruitment and activation of fibroblasts and epithelial cells, making the transition to the next phase in healing. This evidence concerns the gene TNF and infection.