PTCH1 and cancer: Indeed, a variety of primary tumors and cancer cell lines (i.e., lung, ovary, prostate, colon, brain and myeloid leukemia) overexpress Ptch1 (see the Human Protein Atlas website (http://www.proteinatlas.org/ENSG00000185920-PTCH1/cancer, [14] for a review, accessed on 10 January 2022).