In order to validate the anti-tumor effects of GB-13 in vivo, we utilized orthotopic patient-derived murine xenograft models of HGG, including IL-13Rα2-low (SU-DIPG XIII-P), IL-13Rα2-medium (GBM6), and IL-13Rα2-high (PED17) models. The gene discussed is IL13RA2; the disease is neoplasm.