Previously, convection-enhanced delivery (CED) of cintredekin besudotox (IL13-PE38QQR), a wild-type IL-13 pseudomonal exotoxin (PE)-A conjugate that targets both IL-13Rα1 and IL-13Rα2, was evaluated in phase I and phase III clinical trials for DMG and GBM, respectively [33,34,35,36]. Here, IL13 is linked to glioblastoma.