For example, DOX (an immunogenic cell death (ICD) inducer) in a combination with alkylated NLG919 (aNLG919) (an inhibitor of indoleamine 2,3-dioxygenase 1) were loaded into CCPs, and they improved the penetration of the drug into the tumor, exhibited efficient tumor aggregation, and neutralized the acidity of the tumor, resulting in an efficient drug chemotherapy [207]. This evidence concerns the gene IDO1 and neoplasm.