The route of calcium signaling, cholinergic synapse, proteoglycans in cancer, ErbB cascade pathways, GnRH cascade systems, HIF-1 cascade systems, oxytocin cascade systems, lipids and atherosclerosis, cAMP signaling routes, cGMP–PKG signaling pathways, dopaminergic synapses, vascular smooth muscle contractions, cardiomyocyte adrenergic signaling, and leukocyte transendothelial migration are the key KEGG signaling pathways affected by active substances. This evidence concerns the gene PRKG1 and atherosclerosis.