In conclusion, Cucumis sativus L. seed extracts, mainly ethanol and aqueous, exhibited medicinal effects that could be used to treat disorders such as asthma and diarrhea by regulating the contractile response via the L voltage-gated calcium ion channel, M3 muscarinic receptor, or other proteins, such as PLC, to the repolarize membrane action potential. The gene discussed is HSPG2; the disease is asthma.