In addition, the ethanol bioactive compounds modulate the following KEGG signaling pathways: cholinergic synapse; calcium signaling pathway; GnRH signaling system; dopaminergic synapse; lipid and atherosclerosis, and ErbB signaling; contraction of vascular smooth muscle; the production, secretion and action of growth hormones; cardiomyocyte adrenergic signaling; gastric acid secretion; oxytocin signaling; diabetic cardiomyopathy; cancer proteoglycans; and cAMP signaling. Here, GNRH1 is linked to atherosclerosis.