Furthermore, following TGF-β + IL-6 stimulation, the E-Cad mRNA expression was significantly decreased in both RA-FLSs (p = 0.002) and HC-FLSs (p = 0.002), without significant differences between HC- and RA-FLSs (Figure 2B). This evidence concerns the gene TGFB1 and rheumatoid arthritis.