MYC and non-small cell lung carcinoma: Treatment of NSCLC cell lines with a novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) was reported to stimulate apoptosis via a mechanism that is independent of NRs involving upregulation of c-Myc and its downstream targets ornithine decarboxylase (ODC) and cdc25A, showing the c-Myc gene to be crucial in triggering CD437-induced apoptosis [226].