In human NSCLC cells, the purine-based PPAR ligand CB11 (8-(2-aminophenyl)-3-butyl-1,6,7-trimethyl-1H-imidazo [2,1-f]purine-2,4(3H,8H)-dione mediates cell death, ROS production, mitochondrial membrane potential disintegration, and cell cycle arrest [182]. Here, PPARA is linked to non-small cell lung carcinoma.