NR1I2 and non-small cell lung carcinoma: In the case of NSCLC, PXR expression was reported to be upregulated in vitro, and the expressions of cytochrome P450 2C8 (CYP2C8) and P-glycoprotein (P-gp) in NSCLC cell lines were increased after exposure to SR12813, an agonist of PXR.