However, despite the evidence, the use of these drugs is debatable in some cases, and probably it is favored because the knowledge about levels and regulation mechanisms of TNF, TNFR1, and TNFR2 in COVID-19 is limited, and other important factors call into question what side effects can leave the use of TNF immune modulators in viral infections [99]. The gene discussed is TNFRSF1A; the disease is COVID-19.