The anti-TNF biological agents target both tmTNF and sTNF, and all of them trigger diverse effects such as neutralization, apoptosis, and modulation of the immune system; several facts may affect the efficacy of every anti-TNF inhibitor as pharmacokinetic, tissue penetration, affinity, and avidity, among others [91], reasons by which more systematic reviews are required to understand the global impact of anti-TNF therapy in COVID-19. Here, TNF is linked to COVID-19.