Mainly, TNF, IL-6, and IL-8 were lower in COVID-19 compared to patients with septic shock/ARDS, and due to IL-6 and IL-8 was near eightfold lower, it was suggested that cytokine storm does not characterize COVID-19, and it could be one of the reasons for the immunosuppressive therapies fail [45]. This evidence concerns the gene IL6 and COVID-19.