In this study, ten fruit extracts including A. comosus ‘Phulae’ and ‘Pattavia’, C. papaya ‘Khaekdum’ and ‘Khaeknuan’, D. zibethinus ‘Monthong’ and ‘Chanee’, P. guajava ‘Kimju’ and ‘Keenok’ and M. indica ‘Kaew’ and ‘Namdokmai’ were investigated for their in vitro anti-AD properties through inhibition of the key enzymes relevant to AD including AChE, BChE and BACE-1. This evidence concerns the gene ACHE and Alzheimer disease.