Other than the neurotoxicity of Aβ plaques, loss of cholinergic neurons via hydrolysis of the neurotransmitter, acetylcholine, by cholinesterases (ChEs), including acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), can also lead to AD pathogenesis [7]. This evidence concerns the gene BCHE and Alzheimer disease.