In this study, ten fruit extracts including A. comosus ‘Phulae’ and ‘Pattavia’, C. papaya ‘Khaekdum’ and ‘Khaeknuan’, D. zibethinus ‘Monthong’ and ‘Chanee’, P. guajava ‘Kimju’ and ‘Keenok’ and M. indica ‘Kaew’ and ‘Namdokmai’ were investigated for their in vitro anti-AD properties through inhibition of the key enzymes relevant to AD including AChE, BChE and BACE-1. Here, BACE1 is linked to Alzheimer disease.