ACHE and Alzheimer disease: Inhibition of the key enzymes relevant to AD including both ChEs (AChE and BChE) and BACE-1 of ten fruit extracts (A. comosus ‘Phulae’ and ‘Pattavia’, C. papaya ‘Khaekdum’ and ‘Khaeknuan’, D. zibethinus ‘Monthong’ and ‘Chanee’, P. guajava ‘Kimju’ and ‘Keenok’, and M. indica ‘Kaew’, and ‘Namdokmai’) were investigated to screen the top three extracts according to overall strong enzyme inhibitory activity for further analyses on phytochemical profiles, neurotoxicity, and neuroprotective effect on the PC-12 cells and Drosophila model of AD.