CD34 and Schnyder corneal dystrophy: LentiGlobinTM BB305 medicinal product (commercial name Zyntheglo) consists of autologous CD34+ HSPCs transduced with BB305 lentiviral vector that encodes for anti-sickling hemoglobin (HbAT87Q) and showed safety and efficacy in severe SCD and TDT patients with a reduction in transfusion requirements up to transfusion independence in the vast majority of patients [9,11,12,38].