A549 lung adenocarcinoma cells were treated with lovastatin alone or in combination with 0 to 8 Gy IR.  Lovastatin reduced EGF-induced phosphorylation of EGFR and Akt, and IR-induced Akt phosphorylation. Furthermore, lovastatin enhanced AMPK expression, and reduced p53 and the cyclin-dependent kinase inhibitors p21cip1 and p27kip1 expression [32]. This evidence concerns the gene TP53 and lung adenocarcinoma.