The most-frequent hematologic IRAEs after anti-PD-1 or anti-PD-L1 were AIHA, ITP or neutropenia (26%), followed by pancytopenia or aplastic anemia (14%). The median time of onset was 10 weeks; most events were grade 4 and resolved after immunosuppressive therapy. The gene discussed is CD274; the disease is autoimmune hemolytic anemia.