Since the Notch signal pathway regulates the differentiation of breast epithelial cells during normal development, aberrant Notch signaling, as seen by increased NICD release and target gene overexpression, is positively correlated with poor patient prognosis, such as aggressive, metastatic triple negative breast cancer (TNBC) and therapy resistance [30,31,32]. This evidence concerns the gene NOTCH1 and triple-negative breast carcinoma.