Moreover, (3S)-vestitol up-regulated the expression of Socs3 and Dab2 genes (inhibitors of cytokine signaling and the NF-κB pathway), Apoe (related to atherosclerosis control), Igf1 (encoder a protein with analogous effects to insulin) and Fgf10 (fibroblasts growth factor). The gene discussed is APOE; the disease is atherosclerosis.