ACHE and Alzheimer disease: Apart from AChE, other targets and pathogenic mechanisms that, intuitively, seem to have been commonly addressed when designing multitarget anti-AD compounds are glutamante NMDA receptors [36,37], β-amyloid and tau aggregation [38,39], glycogen synthase kinase 3β (GSK-3β) [40], biometal dyshomeostasis [41], monoamine oxidases (MAOs) [42], or oxidative stress [43].