ACHE and Alzheimer disease: Indeed, a large number of multitarget compounds feature pharmacophoric moieties of the approved AChE inhibitors [29,30,31,32], even though publications on multitarget anti-AD agents based on other pharmacophores, especially naturally occurring scaffolds such as β-carbolines [33], naphthoquinones and anthraquinones [34], or chalcones [35], just to name a few of those recently reviewed, are continuously appearing.