TGFB1 and neoplasm: Also, in comparison to free lapachol (IC50 = 6.60 ± 3.1 μM, relative tumor volume = 5.51), LAP-NE showed increased cytotoxicity (IC50 = 7.29 ± 1.79 μM) and reduced relative tumor volume (3.22), thereby providing an effective therapeutic strategy for TNBC therapy [296].