Due to the cationic nature, the dendrimers showed increased internalization in the tumor cells, and the attachment of EGFR-binding peptide 1 and trans-activating transcriptional activator to the dendrimer further enhanced their cellular uptake, which resulted in increased accumulation of drug at the cancer site in vivo, along with effective inhibition of cancer growth and prolonged survival. The gene discussed is EGFR; the disease is cancer.