In this study, initial trials revealed that the quantified Hypericum perforatum extract HP1, with its contents validated by chromatographic methods to confirm its naphtodianthrones, phloroglucinol, and flavonoid contents, inhibits infection by a pseudo-typed VSV virus that harbors the S protein of the SARS-CoV-2 virus (Figure S2), which was further confirmed by testing a range of Hypericum perforatum (HP1) concentrations (μg/mL) (Figure 1). Here, PROS1 is linked to infection.