MYCN and neuroblastoma: Cytotoxic assays using three MYCN-amplified (NGP, LAN-5, and IMR-32), three MYCN-non-amplified NB cell lines (SH-SY5Y, CHLA-255, and SK-N-AS), and three control fibroblast cell lines (WI-38, NIH-3T3, COS-7) showed that HMN-214 significantly and dose-dependently inhibits NB cell proliferation (Figure 2).