Hallmarks of neuropathologies have been identified in the nematode [23,24,25], including those for Parkinson’s Disease [26,27,28,29,30], where there are nematodes that recapitulate the most frequent genetic causes of PD, including LRRK2, PARK2, and DJ-1 (reviewed in Maulik et al. [31] and Cooper and van Raamsdonk [32]), as well as modeling α-synuclein expression [27,33,34]. Here, PRKN is linked to Parkinson disease.