Abuqayyas et al. included the TMDD for two mAbs against tumor-specific carcinoembryonic antigen (CEA) in two xenograft tumors by using the measured CEA concentrations in excised tumors or tumor cells, the internalization rate of the mAb–target antigen complex measured in an in vitro study, and the KD measured by SPR or cell binding assays [117]. Here, CEACAM5 is linked to neoplasm.