First, the QSP model (Figure 5A) was constructed from results of mouse xenograft efficacy study data by incorporating several mechanisms such as pharmacokinetics of PF-06671008, CD3/P-cadherin expression on T cells and tumor cells, T-cell dynamics in blood and tumor, and the formation of PF-06671008-T cell–tumor cell trimer. The gene discussed is CDH3; the disease is neoplasm.