Resveratrol downregulated proinflammatory cytokines and chemokines, such as TNF-α, C-C motif ligand 3 (CCL3), IL-1β, IL-6, and MCP-1, in animals as in human diseases, such as diabetes [17,59], and reduced the expression of the inflammatory and oxidative stress marker CRP, c-Jun N-terminal kinase 1 (JNK-1), IκB kinase β (IKK-β), neutrophil cytosol factor 1 (p47phox), and toll-like receptor 4 (TLR4) in cells from healthy donors [60]. The gene discussed is MAPK8; the disease is diabetes mellitus.