INS and hypertensive disorder: Yogev et al. established that the measurement of C-peptide as a reflection of insulin sensitivity in pregnancy is adequate, being a predictor of preeclampsia independent of BMI and fasting glucose [40]; while Yasuhi et al. demonstrated a relationship between the development of hypertension in mid-pregnancy and the elevation of C-peptide, theorizing an exaggerated response of B-cells to glycemic stimulation reflecting a lower insulin sensitivity [38].