PROS1 and hyperinsulinemic hypoglycemia, familial, 4: Screening for thrombophilia was performed in 83.63% of the reported cases (n = 46), and concomitant thrombophilia was detected in more than one-third of the cases (n = 19, 41.4%), with hyperhomocysteinemia being the most common form (n = 7, 36.84%), followed by protein C and protein S deficiency (n = 6, 31.57%, each).