While the inverse relationship between low-grade endotoxemia and metabolic profile confirms previous data in T2DM [4,21], here we report that in patients with IFG intake of a Mediterranean-type meal or chocolate is associated with a coincident increase of LPS and zonulin, suggesting that changes of gut permeability may account for post-prandial low-grade endotoxemia. This evidence concerns the gene HP and type 2 diabetes mellitus.