A hypertensive nephropathy experiment and a remnant kidney model have demonstrated that fish oil supplementation can attenuate renal injury in rats by reducing NF-κB activation, inhibiting COX-2 expression, reducing reduced nicotinamide adenine dinucleotide phosphate oxidase activation, and consequently inhibiting pro-inflammatory gene transcription and ROS formation [36,37]. This evidence concerns the gene PTGS2 and hypertensive nephropathy.