Based on this evidence, we aimed to evaluate if dietary supplementation with a nutraceutical compound containing standardized bergamot polyphenolic fraction phytosome® and artichoke extracts could positively affect serum lipids concentration and, secondly, insulin sensitivity, systemic inflammation and indexes of non-alcoholic fatty liver disease (NAFLD) in healthy subjects with moderate hypercholesterolemia. This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.