While inducing obesity in both males and females after six weeks on HF [48,72], the increased caloric intake in males during the rest phase results in alterations in the diurnal patterns of circulating metabolic markers, together with a reduced amplitude in the expression of Clock, Bmal1, and Per2 in the AT and the liver [48]. The gene discussed is BMAL1; the disease is obesity due to melanocortin 4 receptor deficiency.