In addition, the uric acid generated during fructose metabolism induces endothelial dysfunction by decreasing the nitric oxide bioavailability and induces endothelial cell senescence while promoting vascular muscle cell hypertrophy, renin-angiotensin activation, and the systemic elevation of protein C reactive; such effects likely contribute to the development of hypertension [94,99]. The gene discussed is REN; the disease is endothelial dysfunction.