RJ also reduced CD3+, CD5+, CD8+ and CD45+ T cells; the secretion of pro-inflammatory cytokines IL-1β and TNF-α; the key inflammatory mediators (COX-2 and NF-κB); and injury caused by tumor necrosis factor in rat colitis induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS). This evidence concerns the gene TNF and colitis.