In addition, low Hoxa5 expression is associated with tumor-node-metastasis (TNM) stages, tumor size and poor prognosis in non-small cell lung cancer, by controlling cell proliferation via the positive regulation of the Cdkn1a expression [106], whereas increasing HOXA5-dependent genes explains the anti-tumor effect of methionine deprivation [101]. This evidence concerns the gene HOXA5 and neoplasm.