Even though the scientific literature presents papers attempting to reveal a possible association between obesity and TNF-α blood levels [28,29,30], few studies are investigating salivary levels [31,32,33] and none of them have focused on preschoolers, or jointly assessed the interplay between obesity, ECC, and TNF-α in the saliva. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.