The multiple points of interaction between interferon (IFN) response, virus infection, and metabolism have been discussed in several reviews including recent reviews by Thaker et al. on viral manipulation of cellular metabolism [1] and by Choi et al. and Sachez-Garcia et al. on the role of the tricarboxylic acid (TCA) cycle as a central metabolic pathway [2,3]. This evidence concerns the gene IFNA1 and viral infectious disease.