CTLA4 and cancer: The ‘immunogenic cascade’ that is from interest can be seen as: targets that are necessary for the interplay between cancer and immune cells (such as CTLA4, PD-1, and PDL-1), targets that define above mentioned cell types (such as CD8), targets that reflect a successful cytotoxic immune reaction (such as granzyme or IFNγ release, T-cell activation).