SIRT1 and metabolic dysfunction-associated steatohepatitis: Furthermore, in a mouse model of non-alcohol steatohepatitis induced by a methionine-choline-deficient diet, RA (10 mg/kg) exhibited a remarkable hepatoprotective potential by decreasing the plasma triglyceride, cholesterol, liver steatosis, and oxidative stress, which was deemed to be related to the activation of the silent information regulator-two 1 (SIRT1)/Nrf2, SIRT1/NF-κB, and SIRT1/peroxisome proliferator-activated receptor α (PPARα) pathways [273].