It was unveiled that RA could effectively inhibit the tumor growth by regulating the secretion of inflammation and angiogenesis cytokines (IL-1β, IL-6, tumor necrosis factor-α (TNF-α), vascular endothelial growth factor, and transforming growth factor-β) and suppressing NF-κB p65 expression in the microenvironment [249]. This evidence concerns the gene TNF and neoplasm.