DNMT1 and neoplasm: Wang et al. [273] showed that oral administration of 60 g per day of BRB powder for 1 to 9 weeks in 20 CRC patients was significantly effective for approximately 4 weeks in modulating the Wnt pathway via demethylation of three tumor-suppressor genes (SFRP2, SFRP5, and WIF1), as well as in decreasing the expression of DNA methyltransferase 1 (DNMT1); the components of BRBs that exerted demethylation effects were not elucidated.