NFKBIA and ulcerative colitis: As demonstrated by Montrose et al. [236], BRB treatment dramatically suppressed the levels of phospho-IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), TNF-α, IL-1β, COX-2, and prostaglandin E2 in an experimental study of induced ulcerative colitis in mice fed a diet containing BRB powder (5 or 10%) for 7–14 days.