Resveratrol has been shown to mimic the effects of calorie restriction by activating protein deacetylase, sirtuin 1 (SIRT1), and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1 α), and thus prolonged the lifespan of mice and prevented damage associated with excessive caloric intake in rodents, such as body fat accumulation and insulin resistance [324,325]. Here, SIRT1 is linked to Insulin resistance.