In a randomized, placebo-controlled trial in 58 men with type 2 diabetes given 240 mL of cranberry juice daily for 12 weeks and in 56 healthy humans supplemented with 240 mL of low-calorie cranberry juice twice daily for 4 weeks, cranberry consumption improved lipid status by increasing serum HDL-C, serum apoA-1, and paraoxonase-1 (PON-1) activity, and by decreasing serum total cholesterol, triglycerides, serum glucose, and apoB, as well as diastolic blood pressure, insulin resistance, and CRP. The gene discussed is PON1; the disease is Insulin resistance.