Shi et al. [267] demonstrated that 2.5%, 5%, or 10% dietary lyophilized strawberries in the AOM/DSS mouse model significantly reduced tumor incidence and expression of proinflammatory mediators (TNF-α, IL-1β, IL-6, COX-2, and iNOS); suppressed nitrosative stress; and decreased the phosphorylation of phosphatidylinositol 3-kinase (PI3-K), Akt (protein kinase B), extracellular signal-regulated kinase (ERK), and NF-κB (Figure 4). This evidence concerns the gene AKT1 and infectious otitis media.