TNF and cancer: Besides, flavonoids are also related to the prevention of chronic inflammation that can foster cancer development, possibly due to the suppression of pro-inflammatory cytokines, including tumor necrosis factor (TNF), interferon (INF)-γ, interleukins (such as IL-1, IL-6, IL-12 and IL-18), and anti-inflammatory cytokines (such as IL-4, IL-10, IL-13, IFN-α) [11].