Therefore, we predict and compare the ability of sulfated (fucoidan) and non-sulfated (alginate) polysaccharides to computationally interact with several targets that are implicated in inflammation, particularly endothelial dysfunction and monocyte migration, including L-selectin, E-selectin, MCP-1, and ICAM-1, by using the most frequently occurring monomer in polysaccharides. Here, CCL2 is linked to endothelial dysfunction.