Kim et al. reported that HFD-induced obese mice administered with spiramycin showed significant reductions in weight gain, serum leptin levels, adipose tissue mass, and liver lipid accumulation, which effectively attenuated high-fat diet (HFD)-induced obesity and hepatic steatosis by inhibiting adipogenesis [12]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.