Obesity was also more frequent in patients with significant liver fibrosis (76.5% versus 50.5%; p = 0.0089), as were values above the upper limit of normality for AST (17.6% versus 2.2%; p = 0.0047) and ALT (23.5% versus 8.6%; p = 0.0348). This evidence concerns the gene GPT and obesity due to melanocortin 4 receptor deficiency.