In the age-adjusted univariate logistic regression analysis, the factors associated with significant liver fibrosis were obesity (OR: 3.0; 95% CI: 1.2–7.5; p = 0.0140); PNPLA3 G/G genotype (OR: 5.0; 95% CI: 1.3–18.1; p = 0.0338); higher serum levels of GGT (OR: 1.021; 95% CI: 1.009–1.033; p = 0.0005) and AST (OR: 1.084; 95% CI: 1.020–1.151; p = 0.0091); and lower platelet count (OR: 0.993; 95% CI: 0.987–0.999; p = 0.0284). The gene discussed is PNPLA3; the disease is obesity due to melanocortin 4 receptor deficiency.