In the age-adjusted univariate logistic regression analysis, the G/G genotype of the SNP rs738409 in PNPLA3 was associated with cirrhosis (OR: 16.4; 95% CI: 3.1–85.8; p = 0.0010), as well as high serum levels of GGT (OR: 1.022; 95% CI: 1.009–1.035; p = 0.0006) and AST (OR: 1.050; 95% CI: 1.004–1.098; p = 0.0325), and lower platelet count (OR: 0.978; 95% CI: 0.966–0.991; p = 0.0009). Here, PNPLA3 is linked to Cirrhosis.