To explore the endocytosis pathways of the two polysaccharides in caco-2 cells, the cells were cultured with CPZ, NYS, AML, CPZ+NYS, CPZ+AML, and NYS+AML, and the resulting Papp values were measured to determine whether clathrin-mediated endocytosis, caveolin-mediated endocytosis, or micropinocytosis play roles in polysaccharide internalization. Here, FRMD7 is linked to acute myeloid leukemia.