Moreover, some literature reported that defensins, as a subcategory of AMPs, were involved in the treatment of infection-induced by Streptococcus, in which the C-terminal 15 amino acids of human beta-defensin-3 (HBD3-C15) inhibited the growth of the cariogenic pathogen Streptococcus mutans and its biofilm formation, and insect Tribolium castaneum defensin1 showed antibacterial activity in an in vitro blood-derived macrophages infection model of Streptococcus pneumoniae [19,20]. The gene discussed is ADSL; the disease is infection.