Furthermore, Yue et al. investigated the associations between SIRT1 gene polymorphisms and diabetic kidney disease, where rs3818292 patients with the GG genotype in the rs3818292 locus were 0.23-fold and 0.21-fold higher than for AA and for AA + AG genotypes, respectively, which in our case, the AG + GG genotypes were associated with 2-fold increased odds of periodontitis development in the dominant model (OR = 1.988; CI = 1.269–3.116; p = 0.003). This evidence concerns the gene SIRT1 and periodontitis.