SIRT1 and squamous cell carcinoma: In the work of Vaiciulis et al., which focused on the study of laryngeals squamous cell carcinoma (LSCC) development probability, carriers of the SIRT1 rs3758391 T/T genotype had a statistically significant increased probability of developing advanced-stage LSCC, according to the codominant and recessive genetic model (OR = 2.387; 95% CI = 1.091–5.222; p = 0.029 and OR = 2.287; 95% CI = 1.070–4.888; p = 0.033, respectively) [27].