The SIRT1 rs7895833 AG genotype was associated with 1.7-fold increased odds of periodontitis development under the codominant and overdominant models (OR = 1.686; CI = 1.172–2.427; p = 0.005; and OR = 1.675; CI = 1.165–2.408; p = 0.005, respectively). Here, SIRT1 is linked to periodontitis.