Abbreviation: Res, resistin; Lep, leptin; MAT, mesenteric adipose tissue; MF, macrophages; LD, lipid droplet; FFA, free fatty acids; T cells, T lymphocytes; B cells, B lymphocytes; DCs, dendritic cells; TNF-α, tumor necrosis factor α; IL-6, interleukin 6; IL-17A, interleukin 17A; CXCR16, C-X-C motif receptor 16; CXCL16, C-X-C motif chemokine 16; KCs, Kupffer cells, NKc, natural killer cells; IFN-γ, interferon-γ; TGFβ, transforming growth factor-β; IR, insulin resistance; and DNL, de novo lipogenesis. The gene discussed is IL17A; the disease is Insulin resistance.