The pathologic hallmarks of DLB are the Lewy bodies, which are clumps of abnormal protein particles that accumulate in the brain within neurons and the key protein involved is polymerized α-synuclein (α-syn), a member of a conserved family of proteins that also includes β-synuclein and γ-synuclein, and was originally described as the precursor protein for the non-amyloid component of Alzheimer’s disease senile plaques [2]. This evidence concerns the gene SNCB and Lewy body dementia.