The aim of this study was to analyze the expression of EGFL7 within the cancer epithelial nest and the adjacent stroma (tumor microenvironment) of High Grade Ovarian Serous Carcinomas (HGOSCs) and its impact on the number of immune cell effectors (CD8+, CD4+) infiltrating cancer epithelial nests, as well as correlation with ICAM-1 expression of adjacent blood vessels. This evidence concerns the gene ICAM1 and cancer.