Tumors having simultaneously EGFL7-positive cancer and endothelial cells (n = 4) were less infiltrated with (IE)CD4+ and (IE)CD8+ lymphocytes compared to the negative ones (n = 55) (median 1.00 range 0.33–3.00 vs. median 5.67, range 0.33–26.33, p = 0.007 and median 1.83 range 1.0 to12.67 vs. 12.67 range 1 to 53, p = 0.013, respectively). The gene discussed is CD8A; the disease is cancer.