FGF21 and metabolic disease: Exploring FGF21 dynamics, as well as the FGF21/FGF1 ratio that has been proposed to regulate lipolysis [98,99] (and even the possible impact of FGF21 on carbohydrate and sugar taste preferences [100] and alcohol consumption [101]), in LMHR as part of the LEM, could provide insight into hormonal mechanisms of metabolic disease.