Genes that are causing DCM encode components of sarcomere (TTN, MYH7, TNNT2, TNNI3, TPM1, ACTC1), sarcomere associated proteins (PLN, BAG3), nuclear membrane (LMNA, EMD), cytoskeleton (DES), outer cellular membrane, extracellular matrix (DMD), ion channels (SCN5A), mitochondrial proteins (TAZ, DNAJC19), and splice-regulating proteins (RBM20) [8]. The gene discussed is DES; the disease is familial dilated cardiomyopathy.