Genes that are causing DCM encode components of sarcomere (TTN, MYH7, TNNT2, TNNI3, TPM1, ACTC1), sarcomere associated proteins (PLN, BAG3), nuclear membrane (LMNA, EMD), cytoskeleton (DES), outer cellular membrane, extracellular matrix (DMD), ion channels (SCN5A), mitochondrial proteins (TAZ, DNAJC19), and splice-regulating proteins (RBM20) [8]. This evidence concerns the gene PLN and familial dilated cardiomyopathy.