In turn, phosphate restriction has the ability to lower FGF23, but, different from PTH secretion from healthy parathyroid glands in a setting of hypercalcemia, FGF23 has never been described to be fully suppressed following hypophosphatemia, for instance when induced by mutations in the renal phosphate transporter NaPi2c which gives rise to hereditary hypophosphatemic rickets with hypercalciuria (HHRH) [8,9]. This evidence concerns the gene FGF23 and hereditary hypophosphatemic rickets.