In turn, phosphate restriction has the ability to lower FGF23, but, different from PTH secretion from healthy parathyroid glands in a setting of hypercalcemia, FGF23 has never been described to be fully suppressed following hypophosphatemia, for instance when induced by mutations in the renal phosphate transporter NaPi2c which gives rise to hereditary hypophosphatemic rickets with hypercalciuria (HHRH) [8,9]. The gene discussed is FGF23; the disease is hereditary hypophosphatemic rickets with hypercalciuria.