The TCA cycle is widely studied in RA pathogenesis, including products such as succinate that activate NLRP3 inflammasome-inducing IL-1β secretion by synovial fibroblasts in a mouse model of RA and Itaconate, a TCA metabolite present high levels in an animal model of RA [114,115]. Here, NLRP3 is linked to rheumatoid arthritis.